What Is PRGF?

PRGF Endoret (plasma rich in growth factors) is one of the most well documented procedures in the world today with clinical data from over 20 years and backed by over 70 scientific publications – more than any PRP procedure. It is now available for facial aesthetics in the UK and treatments are given by the experienced team at 121 Skin in Harley Street.

Graph of healing effects of PRGF vs the natural process

PRGF is the markets first 100% autologous (obtained from the same individual) treatment. This natural ethos we employ means that you will have no bad reactions to the plasma treatment as there is no foreign bodies being used for you to have a reaction to, making it 100% safe. In fact, in none of the treatments carried out during 15 years have any undesired effects been observed.

The Importance Of Your Plasma

There is a reason the best football teams and sports stars on the planet are now using PRGF in other applications such as knee or ligament injuries. Our blood plasma contains proteins that have a biological activity to stimulate and speed up tissue regeneration. Whenever we suffer any sort of injury, we have evolved to senf proteins to that area to stimulate a process that helps to repair that/those tissue affected. The same process can be applied to the skin as we age as the revolutionary treatment can help to regenerate skin tissue, reduce wrinkles by adding real collagen to the face and steadily releasing nutrients and proteins into the skin over time, thus reducing how quickly the skin ages (as well as helping to repair existing damage).

We are now able to isolate the parts of the plasma that speed up this regeneration using the pioneering technology qith the most extensive experience on the market that is 100% biocompatible and safe. PRGF does not include the leucocytes that cause the inflammatory effects you may have read about with celebrities in other procedures such as Vampire Facelift. This is NOT a Vampire Facelift. It Holds both the European CE mark and the American FDA Approval health certifications.

Wrinkles and Aging

Wrinkles are caused by a physiochmical change that are derived from a loss of collagen. Collagen is a very important protein in our skin that gives us the youthful firmness that we lose over time. As we age we also lose elastin which leads to a stretch in our skin as well as the important moisture retaining proteins called glycosaminoglycans.

The aging process is something we must all face, but it can be slowed down and even repaired through regeneration. Aging signs such as wrinkles, ptosis, dyschromia and changes to skin texture, colour, tone, brightness and luminosity can all be improved. The application of PRGF in facial aesthetics gives us the ability to restore the vitality of the skin and reduce the effects of aging by significantly increasing the the supply of nutrients and repairing proteins to the skin, increasing hydration and promoting the formation of blood vessels (anglogenesis).

No allergies or reactions can occur from your own blood plasma being used in your own body. Intercellular communication triggers a chain of biological effects required in the formation and repair of tissue such as cell migration (chemotaxis), proliferation and extracellular matrix synthesis.

Effects of PRGF on Human Skin Diagram

Revolutionary Treatment Benefits

  • Increases skin consistency
  • Reduction of wrinkles
  • Increased brightness
  • No change in facial expression
  • Biostimulation of the treated areas
  • Compatible with other antiaging treatments
  • Increased facial hydration and cooling sensation
  • Slow aging process of the skin
  • Regenerative and corrective properties of the skin
  • regeneration and rejuvenation of tissue
  • collagen production is increased
  • starts blood vessel growth
  • cell differentiation is encouraged, with stimulation of all the different cells needed for regeneration
  • formation of extra cellular matrix – connective tissue vital to holding everything together, giving it shape and form
  • adhesion of tissue, particularly relating to skin flaps, bone grafts and trauma. This helps tissues to stick together and become strong

The Harley Street Treatment Experience

After your initial consultation in our relaxing Harley Street suite, anaesthetic cream will be applied to the face to ensure a virtually painless treatment. Whilst the anesthetic is applied, blood will be taken by your experienced doctor to be used in the centrifuge. The blood will be spun to obtain 4 fractions in total containing blood, white blood cells, plasma fraction 1 and plasma fraction 2. The white and red blood cells fractions are not used. The reason the white blood cells and blood cells are not used (unlike in other similar procedures such as the Vampire Facelift) is because these fractions cause inflammation.

You may have seen celebrities with puffed up faces and swelling as a result of this. This will not happen with PRGF as the inflammatory components are removed.

The treatment will take approximately 1 hour in Harley Street with minimum to no down time observed. You can return to work the next day. Remember, you cannot have adverse reactions to your own blood! The plasma is then prepared and injected into various positions of the face and neck. You should feel no pain as the anaesthetic cream will have taken effect.

It is recommended to have exactly 3 treatments over the course of 3 months as this will create a nutrient packed matrix inside your skin that will release proteins over the next 12 months to help slow down aging and stimulate regeneration of the skin. This should be repeated annually for optimum effect.

estetica The idea of using PRGF®-Endoret® to treat facial ageing is the result of a wide range of basic and clinical observations concerning its beneficial effect after its application to other tissues. The capacity of PRGF®-Endoret® to activate the regeneration of tissues can counteract the degenerative changes that take place in the skin after the third decade of life, improving its tone and plasticity.

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